Author(s): Pukar Khanal
Drug discovery/invention to manage/treat multifaced diseases pathogenesis is always challenging as these conditions are complex due to the involvement of multiple proteins and pathways. Further, the current choice of therapeutic agents to treat numerous diseases are single-target agents that were developed based on the concept of “lock and key” or “one drug-one protein interaction”. Although these agents are effective in managing diseases and cover the major portion of the prescription they are associated with multiple severe side effects. Now in the present era, one should understand if the drugs were designed as single target molecules towards particular pharmacological activity, why these side effects occur?