Enliven: Challenges in Cancer Detection and Therapy

In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy.

Image Article

In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Cavity Ring–Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy. It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-4) [1-101].

It can be concluded that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-4) [1-101].

Figure 1:Cavity Ring–Down Spectroscopy (CRDS) analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

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Figure 1: Cavity Ring–Down Spectroscopy (CRDS) analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

Figure 2:Circular Dichroism Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

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Figure 2: Circular Dichroism Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

Figure 3:Cold Vapour Atomic Fluorescence Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

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Figure 3: Cold Vapour Atomic Fluorescence Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

Figure 4:Correlation Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

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Figure 4: Correlation Spectroscopy analysis of malignant cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time [1-101].

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29. Heidari A (2016) Combined Theoretical and Computational Study of the Belousov–Zhabotinsky Chaotic Reaction and Curtius Rearrangement for Synthesis of Mechlorethamine, Cisplatin, Streptozotocin, Cyclophosphamide, Melphalan, Busulphan and BCNU as Anti–Cancer Drugs. Insights Med Phys 1: 2.


30. Heidari A (2016) A Translational Biomedical Approach to Structural Arrangement of Amino Acids’ Complexes: A Combined Theoretical and Computational Study. Transl Biomed 7: 2.


31. Heidari A (2016) Ab Initio and Density Functional Theory (DFT) Studies of Dynamic NMR Shielding Tensors and Vibrational Frequencies of DNA/RNA and Cadmium Oxide (CdO) Nanoparticles Complexes in Human Cancer Cells. J Nanomedine Biotherapeutic Discov 6: e144.


32. Heidari A (2016) Molecular Dynamics and Monte–Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study. J Glycobiol 5: e111.


33. Heidari A (2016) Synthesis and Study of 5–[(Phenylsulfonyl)Amino]–1,3,4–Thiadiazole–2–Sulfonamide as Potential Anti–Pertussis Drug Using Chromatography and Spectroscopy Techniques. Transl Med (Sunnyvale) 6: e138.


34. Heidari A (2016) Nitrogen, Oxygen, Phosphorus and Sulphur Heterocyclic Anti–Cancer Nano Drugs Separation in the Supercritical Fluid of Ozone (O3) Using Soave–Redlich–Kwong (SRK) and Pang–Robinson (PR) Equations. Electronic J Biol 12: 3.


35. Heidari A (2016) An Analytical and Computational Infrared Spectroscopic Review of Vibrational Modes in Nucleic Acids. Austin J Anal Pharm Chem 3: 1058.


36. Heidari A, Brown C (2016) Phase, Composition and Morphology Study and Analysis of Os–Pd/HfC Nanocomposites. Nano Res Appl 2: 1.


37. Heidari A, Brown C (2016) Vibrational Spectroscopic Study of Intensities and Shifts of Symmetric Vibration Modes of Ozone Diluted by Cumen.  International Journal of Advanced Chemistry 4:5–9.


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40. Heidari A (2016) Genomics and Proteomics Studies of Zolpidem, Necopidem, Alpidem, Saripidem, Miroprofen, Zolimidine, Olprinone and Abafungin as Anti–Tumor, Peptide Antibiotics, Antiviral and Central Nervous System (CNS) Drugs. J Data Mining Genomics & Proteomics 7: e125.


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42. Heidari A (2016) Biotranslational Medical and Biospectroscopic Studies of Cadmium Oxide (CdO) Nanoparticles–DNA/RNA Straight and Cycle Chain Complexes as Potent Anti–Viral, Anti–Tumor and Anti–Microbial Drugs: A Clinical Approach. Transl Biomed 7: 2.


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45. Heidari A (2016) Linear and Non–Linear Quantitative Structure–Anti–Cancer–Activity Relationship (QSACAR) Study of Hydrous Ruthenium (IV) Oxide (RuO2) Nanoparticles as Non–Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Anti–Cancer Nano Drugs. J Integr Oncol 5: e110.


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47. Heidari A (2016) Coplanarity and Collinearity of 4’–Dinonyl–2,2’–Bithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti–Tumor Nano Drug. Int J Drug Dev & Res 8: 007–008.


48. Heidari A (2016) A Pharmacovigilance Study on Linear and Non–Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for the Prediction of Retention Time of Anti–Cancer Nano Drugs under Synchrotron Radiations. J Pharmacovigil 4: e161.


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50. Heidari A (2016) A Successful Strategy for the Prediction of Solubility in the Construction of Quantitative Structure–Activity Relationship (QSAR) and Quantitative Structure–Property Relationship (QSPR) under Synchrotron Radiations Using Genetic Function Approximation (GFA) Algorithm. J Mol Biol Biotechnol 1: 1.


51. Heidari A (2016) A Gastrointestinal Study on Linear and Non–Linear Quantitative Structure (Chromatographic) Retention Relationships (QSRR) Models for Analysis 5–Aminosalicylates Nano Particles as Digestive System Nano Drugs under Synchrotron Radiations. J Gastrointest Dig Syst 6: e119.


52. Heidari A (2016) DNA/RNA Fragmentation and Cytolysis in Human Cancer Cells Treated with Diphthamide Nano Particles Derivatives. Biomedical Data Mining 5: e102.


53. Heidari A (2016) Computational Study on Molecular Structures of C20, C60, C240, C540, C960, C2160 and C3840 Fullerene Nano Molecules under Synchrotron Radiations Using Fuzzy Logic. J Material Sci Eng 5: 282.


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55. Heidari A (2016) Graph Theoretical Analysis of Zigzag Polyhexamethylene Biguanide, Polyhexamethylene Adipamide, Polyhexamethylene Biguanide Gauze and Polyhexamethylene Biguanide Hydrochloride (PHMB) Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a–BNNTs) and Hexagonal Boron Nitride Nanotubes (h–BNNTs). J Appl Computat Math 5: e143.


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57. Heidari A (2016)The Impact of High Resolution Imaging on Diagnosis. Int J Clin Med Imaging 3: 1000e101.


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60. Heidari A (2016) Mathematical Equations in Predicting Physical Behavior. J Appl Computat Math 5: 5, 2016.


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64. Heidari A (2016) Cancer Risk Prediction and Assessment in Human Cells under Synchrotron Radiations Using Quantitative Structure Activity Relationship (QSAR) and Quantitative Structure Properties Relationship (QSPR) Studies. Int J Clin Med Imaging 3: 516.


65. Heidari A (2016) A Novel Approach to Biology. Electronic J Biol 12: 4.


66. Doarn CR (2016) Innovative Biomedical Equipment’s for Diagnosis and Treatment. J Bioengineer & Biomedical Sci 6: e123.


67. Heidari A (2016) Integrating Precision Cancer Medicine into Healthcare, Medicare Reimbursement Changes and the Practice of Oncology: Trends in Oncology Medicine and Practices. J Oncol Med & Pract 1: 2.


68. Heidari A (2016) Promoting Convergence in Biomedical and Biomaterials Sciences and Silk Proteins for Biomedical and Biomaterials Applications: An Introduction to Materials in Medicine and Bioengineering Perspectives. J Bioengineer & Biomedical Sci 6: 3.


69. Heidari A (2017) X–Ray Fluorescence and X–Ray Diffraction Analysis on Discrete Element Modeling of Nano Powder Metallurgy Processes in Optimal Container Design. J Powder Metall Min 6: 1.


70. Heidari A (2017) Biomolecular Spectroscopy and Dynamics of Nano–Sized Molecules and Clusters as Cross–Linking–Induced Anti–Cancer and Immune–Oncology Nano Drugs Delivery in DNA/RNA of Human Cancer Cells’ Membranes under Synchrotron Radiations: A Payload–Based Perspective. Arch Chem Res 1: 2.


71. Heidari A (2017) Deficiencies in Repair of Double–Standard DNA/RNA–Binding Molecules Identified in Many Types of Solid and Liquid Tumors Oncology in Human Body for Advancing Cancer Immunotherapy Using Computer Simulations and Data Analysis. J Appl Bioinforma Comput Biol 6: 1.


72. Heidari A (2017) Electronic Coupling among the Five Nanomolecules Shuts Down Quantum Tunneling in the Presence and Absence of an Applied Magnetic Field for Indication of the Dimer or other Provide Different Influences on the Magnetic Behavior of Single Molecular Magnets (SMMs) as Qubits for Quantum Computing. Glob J Res Rev 4: 2.


73. 73. Heidari A (2017) Opinion on Computational Fluid Dynamics (CFD) Technique. Fluid Mech Open Acc 4: 157.


74. Heidari A (2017) Polymorphism in Nano–Sized Graphene Ligand–Induced Transformation of Au38–xAgx/xCux(SPh–tBu)24 to Au36–xAgx/xCux(SPh–tBu)24 (x = 1–12) Nanomolecules for Synthesis of Au144–xAgx/xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p–MBA)60, (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] Nano Clusters as Anti–Cancer Nano Drugs. J Nanomater Mol Nanotechnol 6: 3.


75. Heidari A (2017)Biomedical Resource Oncology and Data Mining to Enable Resource Discovery in Medical, Medicinal, Clinical, Pharmaceutical, Chemical and Translational Research and Their Applications in Cancer Research. Int J Biomed Data Min 6: e103.2017.


76. Heidari A (2017) Study of Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Olympiadane Nanomolecules as Agent for Cancer Enzymotherapy, Immunotherapy, Chemotherapy, Radiotherapy, Hormone Therapy and Targeted Therapy under Synchrotorn Radiation. J Dev Drugs 6: e154.


77. Heidari A (2017) A Novel Approach to Future Horizon of Top Seven Biomedical Research Topics to Watch in 2017: Alzheimer's, Ebola, Hypersomnia, Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Microbiome/Antibiotic Resistance and Endovascular Stroke. J Bioengineer & Biomedical Sci 7: e127.


78. . Heidari A (2017) Opinion on Computational Fluid Dynamics (CFD) Technique. Fluid Mech Open Acc 4: 157.


79. Heidari A (2017)  Concurrent Diagnosis of Oncology Influence Outcomes in Emergency General Surgery for Colorectal Cancer and Multiple Sclerosis (MS) Treatment Using Magnetic Resonance Imaging (MRI) and Au329(SR)84, Au329–xAgx(SR)84, Au144(SR)60, Au68(SR)36, Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au21S(SAdm)15, Au36(pMBA)24 and Au25(pMBA)18 Nano Clusters. J Surgery Emerg Med 1: 21.


80. Heidari A (2017) Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy). Cell Biol (Henderson, NV) 6: 1.


81. Heidari A (2017) Changing Metal Powder Characteristics for Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins Adjustment in Cancer Metastases Induced by Osteosarcoma, Chondrosarcoma, Carcinoid, Carcinoma, Ewing’s Sarcoma, Fibrosarcoma and Secondary Hematopoietic Solid or Soft Tissue Tumors. J Powder Metall Min 6: 170.


82. Heidari A (2017)  Nanomedicine–Based Combination Anti–Cancer Therapy between Nucleic Acids and Anti–Cancer Nano Drugs in Covalent Nano Drugs Delivery Systems for Selective Imaging and Treatment of Human Brain Tumors Using Hyaluronic Acid, Alguronic Acid and Sodium Hyaluronate as Anti–Cancer Nano Drugs and Nucleic Acids Delivery under Synchrotron Radiation. Am J Drug Deliv 5: 2.


83. Heidari A (2017) Clinical Trials of Dendritic Cell Therapies for Cancer Exposing Vulnerabilities in Human Cancer Cells’ Metabolism and Metabolomics: New Discoveries, Unique Features Inform New Therapeutic Opportunities, Biotech's Bumpy Road to the Market and Elucidating the Biochemical Programs that Support Cancer Initiation and Progression. J Biol Med Science 1: e103.


84. Heidari A (2017) The Design Graphene–Based Nanosheets as a New Nanomaterial in Anti–Cancer Therapy and Delivery of Chemotherapeutics and Biological Nano Drugs for Liposomal Anti–Cancer Nano Drugs and Gene Delivery. Br Biomed Bull 5: 305.


85. Heidari A (2017) Integrative Approach to Biological Networks for Emerging Roles of Proteomics, Genomics and Transcriptomics in the Discovery and Validation of Human Colorectal Cancer Biomarkers from DNA/RNA Sequencing Data under Synchrotron Radiation. Transcriptomics 5: e117.


86. Heidari A (2017)  Elimination of the Heavy Metals Toxicity and Diseases in Disruption of Extracellular Matrix (ECM) Proteins and Cell Adhesion Intelligent Nanomolecules Adjustment in Cancer Metastases Using Metalloenzymes and under Synchrotron Radiation. Lett Health Biol Sci 2: 1–4.


87. Heidari A (2017) Treatment of Breast Cancer Brain Metastases through a Targeted Nanomolecule Drug Delivery System Based on Dopamine Functionalized Multi–Wall Carbon Nanotubes (MWCNTs) Coated with Nano Graphene Oxide (GO) and Protonated Polyaniline (PANI) in Situ During the Polymerization of Aniline Autogenic Nano particles for the Delivery of Anti–Cancer Nano Drugs under Synchrotron Radiation. Br J Res 4: 16.


88. Heidari A (2017) Sedative, Analgesic and Ultrasound–Mediated Gastrointestinal Nano Drugs Delivery for Gastrointestinal Endoscopic Procedure, Nano Drug–Induced Gastrointestinal Disorders and Nano Drug Treatment of Gastric Acidity. Res Rep Gastroenterol 1:1.


89. Heidari A (2017) Synthesis, Pharmacokinetics, Pharmacodynamics, Dosing, Stability, Safety and Efficacy of Orphan Nano Drugs to Treat High Cholesterol and Related Conditions and to Prevent Cardiovascular Disease under Synchrotron Radiatio. J Pharm Sci Emerg Drugs 5: 1.


90. Heidari A (2017) Non–Linear Compact Proton Synchrotrons to Improve Human Cancer Cells and Tissues Treatments and Diagnostics through Particle Therapy Accelerators with Monochromatic Microbeams. J Cell Biol Mol Sci 2: 1–5.


91. 91. Heidari A (2017) Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood–Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. J Med Chem Toxicol 2: 1–5.


92. Heidari A (2017) Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood–Brain Barrier (BBB) Translocation to Targeted Deliver Anti–Cancer Nano Drugs into the Human Brain to Treat Alzheimer’s Disease under Synchrotron Radiation. J Nano technol Material Sci 4: 1–5.


93. Ricardo Gobato, Heidari A (2017) Calculations Using Quantum Chemistry for Inorganic Molecule Simulation BeLi2SeSi. American Journal of Quantum Chemistry and Molecular Spectroscopy 2: 37–46.


94. Heidari A (2017)  Different High–Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Lung Cancer Translational Anti–Cancer Nano Drugs Delivery Treatment Process under Synchrotron and X–Ray Radiations. J Med Oncol 1: 1.


95. Heidari A (2017)  A Modern Ethnomedicinal Technique for Transformation, Prevention and Treatment of Human Malignant Gliomas Tumors into Human Benign Gliomas Tumors under Synchrotron Radiation. Am J Ethnomed 4: 10.


96. Heidari A (2014) An Investigation of the Role of DNA as Molecular Computers: A Computational Study on the Hamiltonian Path Problem. International Journal of Scientific & Engineering Research 5: 1884–1889.


97. . Heidari A (2017) Active Targeted Nanoparticles for Anti–Cancer Nano Drugs Delivery across the Blood–Brain Barrier for Human Brain Cancer Treatment, Multiple Sclerosis (MS) and Alzheimer's Diseases Using Chemical Modifications of Anti–Cancer Nano Drugs or Drug–Nanoparticles through Zika Virus (ZIKV) Nanocarriers under Synchrotron Radiation. J Med Chem Toxicol 2: 1–5.


98. Heidari A (2017) Investigation of Medical, Medicinal, Clinical and Pharmaceutical Applications of Estradiol, Mestranol (Norlutin), Norethindrone (NET), Norethisterone Acetate (NETA), Norethisterone Enanthate (NETE) and Testosterone Nanoparticles as Biological Imaging, Cell Labeling, Anti–Microbial Agents and Anti–Cancer Nano Drugs in Nano medicines Based Drug Delivery Systems for Anti–Cancer Targeting and Treatment. Parana Journal of Science and Education 3: 10–19.


99. Heidari A (2017)  A Comparative Computational and Experimental Study on Different Vibrational Bio spectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open J Anal Bioanal Chem 1: 014–020.


100. Heidari A (2017) Combination of DNA/RNA Ligands and Linear/Non–Linear Visible–Synchrotron Radiation–Driven N–Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti–Cancer Activity. Enz Eng 6: 1.


101. Heidari A Investigation of Anti–Cancer Nano Drugs’ Effects’ Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X–Ray Radiations with the Passage of Time Using Mathematica. Current Trends Anal Bioanal Chem 1(1): 36